A brief history of oral peptides (seangeiger.substack.com)
52 points by odedfalik a day ago
celltalk 3 hours ago
It’s a great read but is this really the history of oral peptides?
abainbridge 2 hours ago
Yep, I think it is. The point is there's almost no history of oral peptides, other than stomachs destroying them.
FTA: "So to summarize the state of the art in oral peptide delivery: there are exactly two FDA-approved products that use permeation enhancers to get peptides into your bloodstream through your GI tract. Both achieve sub-1% bioavailability. Both required over a decade of development, thousands of clinical trial participants, and hundreds of millions of dollars."
pstuart 20 minutes ago
Would a sublingual dose be possible/more effective? Research in other (um, yeah, medicinal!) compounds shows that it can be an effective pathway to the bloodstream rather than trying to survive the digestive system.
CGMthrowaway 14 minutes ago
rodarmor 16 minutes ago
Kaminsk13 a day ago
I'm not sure why the hims investors ever thought that this was legal
InsideOutSanta 3 hours ago
They probably didn't, they just took the bet that this was one of the crimes that are currently legal, like crypto scams, environmental crimes, bribery, and tay evasion for the rich.
badrequest 2 hours ago
Some of the most profitable ventures this century have been objectively illegal, but when you know you won't go to prison for violating the law, why would you care to follow it?
pixl97 15 minutes ago
The process of chlorinating water was first done illegally.
CGMthrowaway 8 minutes ago
kps 3 hours ago
The charitable assumption is that investors weren't aware it was a problem.
badc0ffee an hour ago
Informative article but I feel like it could have benefited from a paragraph about what Hims is. I had never heard of them before.
Boot2Root a day ago
Appreciate the perspective on the risk of dubious formulations. Consequences are far more than cosmetic.
ftchd 3 hours ago
thanks, needed this for a mogging session later
ydai0531 a day ago
great read!