Spider venom kills varroa mites without harming honeybees (connectsci.au)
244 points by Jedd 12 hours ago
worldvoyageur 4 hours ago
I grew up on a farm on which the apiary and all connected with it was a major part of the farm's output. Honey, beeswax, nukes (a queen and 10K or so worker bees as a starter colony, sold to other apiaries in the spring if they'd had too many winter losses), fertilizing services (drop a couple colonies off at a berry farm after dark, pick the colonies up two weeks later, profit!) and other products.
It's been over ten years since I spent any serious time with bees, but the bees themselves did a great job on the varroa mites. Sentinel bees at the hive entrance would pick the mites off the incoming bees. The problem was if the colony had a solid floor the mites would just climb back onto the next bee that passed nearby. If the solid colony floor was replaced with a mesh, the mites would fall through to the ground below while the bees could still go about their business.
We would still sometimes treat for varroa, but making it easier for the bees to handle varroa how they had evolved to was the first line of defence.
This was Canada, regular Italian bees, hard winter kills of whatever wasn't properly winterized.
ct0 3 hours ago
There is recent article from scientific beekeeper that goes into detail about these using their own venom as a cleaning agent.
andai 2 hours ago
Fascinating, thanks. What does winterization involve? I looked it up online but there's a whole bunch of different information.
Also how cold does it get?
worldvoyageur 7 minutes ago
A typical winter day would be a high of -6 Celcius and a low of -20, but there would be cold snaps of -20 or colder. Winterization itself was several things.
1. In late fall we'd make sure each colony had enough honey to fuel them through to spring (a quick lift would tell you). If short, we'd put sugar saturated water in a tray on top of the colony. The bees would move the sugar into the colony and a couple days later we'd take out the bone dry trays. Failing to ensure enough fuel meant certain death for the colony, though for some in the trade the math was that it was cheaper to buy nukes (a colony nucleus of a queen and some workers) in the spring. Our math was that We liked to have strong colonies in the spring to sell nukes.
2. A bee colony is basically a rectangular box sitting on a frame. We had rectangular insulation that stored flat but easily expanded to slide over each colony before the first snow. The colonies would get buried in snow, which was excellent extra insulation.
3. The bees themselves did the work to survive the winter. They'd huddle in a ball, burning honey to generate heat (a bee could heat itself to something like 40 degrees C), fanning their wings to spread the heat. The bees in the centre of the ball would move out to the periphery while those on the periphery would move into the center.
A cold snap that lasted too long was a disaster as the bees would tighten the ball for greater warmth and then run out of honey within the ball. Those colonies would die. In the spring you'd find the tightly clustered ball of bees, dead, surrounded by honey not that far outside the ball.
You needed at least one brief warming period in a cold snap in which the ball of bees would expand, find a new patch on unconsumed honey in the hive and then recontract around the honey.
If we did our work properly in the fall, we'd have 90% or more of our colonies make it to spring, most strong so we could make nukes to replace our losses and sell on the extras.
achierius an hour ago
> We would still sometimes treat for varroa, but making it easier for the bees to handle varroa how they had evolved to was the first line of defence
I thought this was very dependent on the species -- European honeybees did not evolve to deal with varroa mites, because the mites originated in Asia. Asian honeybees, and honeybees bred with them, do have better ways of dealing with the mite; you said regular Italian bees, were they really not hybridized?
I don't have any actual field experience here, just curious!
tomaytotomato 9 hours ago
Check out Paul Stamets' research using Mycelium to give honeybees an immuneboost.
thatspartan 6 hours ago
TIL that the Star Trek Stamets character is based on a real world Paul Stamets working on actual Mycelium. Wow
temp0826 3 hours ago
TIL that there is a character based off him in Star Trek??
dreamcompiler 3 hours ago
And Anthony Rapp (the actor who plays him) went through some awful stuff that made him famous for another reason and he seems to have come out stronger. Good for him.
As for the whole mycelium plot in Discovery, I found it so ridiculous that I refuse to consider that show canon.
veonik an hour ago
ghostbrainalpha an hour ago
schainks 10 hours ago
Honeybees are not native to North America.
It is great and currently necessary we use them the way we do. It makes one wonder in the age of AI and evolving farm practices, can we start finding ways to cultivate already-climate-adapted native bees to do the work? Can we leverage adaptations for specific crops?
I get it that honeybees work great at pollinating monoculture fields, etc., but that does not change the fact we are perpetuating a square peg in round hole problem and pushing it very very far right now, at greater and greater cost, all while climate change is fighting us.
looping__lui 10 hours ago
I suppose honey bees are not native in North America pretty much the same way as the human species?
I don’t quite understand why there seems to be a pretty persistent thread around “honey bees are invasive and harm the ecosystem by stealing all the food from the native bees and doing all their pollination; that’s why they decline” - when at the same time the use of pesticides is so rampant that insects are literally gone entirely.
Honey bees are not great and reliable pollinators btw.
So the solution is: more genetically modified crops? More pesticides?
Unless “we need to stop our use of pesticides and we should also acknowledge that honey bees are an invasive species and consider making changes to the way we do monocultures” are in the same sentence this entire “honey bees are invasive” argument just feels super weird. Pesticides kill native pollinators. It’s not the honey bees.
Edit: and just to be clear - honey bees do not survive in the wild by themselves anymore due to varroa mites. They essentially depend on humans to protect them. That’s what the entire purpose of this article is about. So, if humans stopped keeping honey bees - they’d have a pretty hard time surviving in the wild on their own.
dqv 3 hours ago
> I suppose honey bees are not native in North America pretty much the same way as the human species?
No? Well not in a way that wouldn't be stretching an owl over a globe. But Carolina Jessamine is toxic to honeybees and not natives (or at least there exist native bees who have adapted to not slurp on it if it is toxic to them). That doesn't stop people from spreading the lie that Carolina Jessamine "hurts bees". It hurts some species of bees. To transfer this concept to the human population, you'd have to start arguing that there are different species of humans or, again, construct a stretching-an-owl-over-a-globe argument.
And people can't mention every caveat in every discussion, sorry. You've really just constructed a strawman.
In a 40-minute discussion with someone like Doug Tallamy, both the issue of invasive honeybees and pesticides will come up. The venn diagram of people who care about both things is very close to a circle.
Also, as to your edit - that honeybees rely on humans doesn't change their impact on native bee populations, which is they outcompete native bees.
There's nothing weird about correcting the popular ignorant assumption that the only pollinator that matters is honeybees.
anjel 3 hours ago
Robotic polinators ftw.
ghssds 2 hours ago
mastermage 9 hours ago
An idea that sprang to mind and please point me out at which points its unrealistic and why because I am talking completely out of my ass here. If we want to reduce mono culture but we still need to somehow figure out how to provide humanity. Could large scale vertical farms, in Green Houses reduce the footprint of monocultures? By being more productive year round? Or is that just technolgist delusions of mine?
j4k0bfr 9 hours ago
forlorn_mammoth 7 hours ago
bell-cot 7 hours ago
looping__lui 8 hours ago
gadders 10 hours ago
>>Honeybees are not native to North America.
Neither are horses.
I guess the issue is you don't get honey with the native bees.
lebuffon an hour ago
There were native horses, in fact the genus began in N. America and migrated out. Remains have been found in permafrost in Northern Canada. They went extinct about 12,700 years ago, sometime after humans arrived.
nerbert 9 hours ago
Neither with horses
gadders 8 hours ago
colechristensen 9 hours ago
A quite similar horse species went extinct in North America ~10,000 years ago likely due to humans.
The horse ancestor species come from the Americas and migrated to Eurasia over the bearing land bridge.
Horses were only missing from North America for 10,000 of the last 50 million years.
firen777 9 hours ago
bregma 7 hours ago
The catch is that native North American pollinators are adapted to native North American flowers and have a great deal of difficulty pollinating introduced species that are native to Eurasia. Given the vast majority of commercial crops are not native plant species, the only way to mass pollinate them is to use non-native pollinators.
Also, few native North American bee species are eusocial. That's another quality one would need to be able to use them the same way as commercial honeybees are used today.
The there is the issue of honey production.
dqv 2 hours ago
That's not true. We have a lot of generalist bees (and other pollinators too! bees aren't the only ones that pollinate!) that can pollinate the Eurasian crops. This is also true for any other crop on any other continent. And I am dubious as to your claim about major crops. Soybeans, for example, are self-pollinating, so it would seem any generalist bee can pollinate soybean crops for better yields.
This is an issue of biodiversity. If we rely on a mono-species for pollination and that mono-species goes extinct or its population plummets, then our crop yields are down 20% until we can build up other bee populations.
This is about giving back to Nature so that She may continue to cradle us. And She does tend to punish us for "optimizing" toward one specific species.
We do enough already taking crops from one part of the world and putting them elsewhere. In exchange for that, we really ought to be trying to support the native wildlife as much as possible. The Europeans can have their honey, and I will have my maple syrup. On occasion, of course, so as not to upset Nature.
grayhatter 4 hours ago
Did you just ask if we could use AI to create new/better honey bees?
xgulfie 4 hours ago
Grok, pollinate the flowers
halflife 10 hours ago
If they are not native, how did plant propagate seeds? Flies? Wasps? Butterflies?
Jedd 9 hours ago
Amusingly, propagate has a horticultural, and non-horticultural meaning, and it's not obvious which one you're using there, because the bee's role is long over by the time the seed is ready to go out into the world.
Pollen can be carried (as noted by sibling and you) by lots of different insects, and there's myriad solitary and other (by conventional standards) weird bee species around, plus lots of plants are happy to pollinate themselves (tomato is a good example) or rely on wind (corn/maize is the famous example there).
When the common honeybee landed in the continental USA, about four centuries ago, the same people also brought in lots of (other) european plant species that had co-existed with Apis mellifera for millennia.
halflife 5 hours ago
EdwardDiego 10 hours ago
Native bees. Apis mellifera are introduced bees across most of the world.
But yes, there are other pollinators like butterflies, moths, flies, birds, etc.
halflife 5 hours ago
NoMoreNicksLeft 10 hours ago
You could pick up a catalog from any of these places and find half a dozen different species of bees to cultivate for pollination. Blue mason bees come to mind. Anything that's even slightly domesticatable is being pursued. Some of these bees are loners too, perfect for the hipster crowd.
roboben 11 hours ago
The hard truth these days is that the work of bee keeping is like 80% keeping the mites in check. Plus all current treatments render the honey inedible so you can only do it at the end of the season.
agilob 11 hours ago
To add, varroa quickly gains immunity to the pharmaceutical treatment we have, so the same medication cannot be used 2 years in a row. Most popular treatment from late 90s that used to kill 99% of varroa is now completely ineffective.
It was explained to me this is well planned and solved in Czechia. Varroa treatment is refunded my the government, but only one type of medication every 6 months. It's cheaper for beekeepers to use whatever the government gives them for free, than use something else. And the medication is free only for a few weeks, so everyone will use it at the same time.
CommonGuy 4 hours ago
Acid (oxalic acid, formic acid) treatments can be used multiple times in a row, but are harder on the bees
throwaway2037 5 hours ago
I did some light research on the topic.
Wiki page about the specific parasite that affects honey bees: https://en.wikipedia.org/wiki/Varroa_destructor
On that page there mention of "honey bee genetics" as a form of parasite control. It is called "Varroa sensitive hygiene". Wiki page: https://en.wikipedia.org/wiki/Varroa_sensitive_hygiene
> Varroa sensitive hygiene (VSH) is a behavioral trait of honey bees (Apis mellifera) in which bees detect and remove bee pupae that are infested by the parasitic mite Varroa destructor. VSH activity results in significant resistance to the mites.
It sounds like you need to buy better gene stock in your area. USDA started publishing about this finding in 1997, almost 30 years ago.CommonGuy 4 hours ago
I have bees myself. Beekeepers and scientists all over the world are trying to breed better bees with improved VSH. While it may work in a laboratory, it does not seem to work consistently in practice. You cannot just buy a "VSH colony/queen" and no longer treat Varroa mites. Even with careful breeding, the VSH behavior often vanishes (or is greatly reduced) after 1-2 generations.
Of course having only colonies with a strong VSH would be the end goal so we no longer need to treat our bees. But until then, better treatments are needed.
throwaway2037 3 hours ago
lavela 3 hours ago
As far as I know VSH is suppressed when you take away the honey. Taking away the honey puts the colony in constant food stress, which suppresses reproductive work.
mrweasel 8 hours ago
Depending on location acid treatments can only be done after the honey harvest anyway, due to temperatures, so it's a minor issue.
You can also use drone frames, and remove drone brood during the summer, or cage the queen a period of time. These are both mechanical treatments and obviously doesn't hurt the honey.
moebrowne 9 hours ago
> Plus all current treatments render the honey inedible
Formic acid is one of the few treatments which is acceptable to use while honey is present.
brikym 9 hours ago
Last I checked researchers were trying to evolve bees to be mite resistant. Is this something you've come across?
shevy-java 11 hours ago
No. The mites are not what is killing the bees.
And, by the way - natural pathogens exist in just about any population. These very, very rarely led to extinction. There is a media trend to claim the mites are at fault. This reminds me of prior fault yielding e. g. "mad cow disease" - and then the media also stopped doing any further investigation at that point. It's as if they have break points where you can not go past those points. Now it is the mites that get blamed.
MrLeap 11 hours ago
Lotta unsubstantiated claims you're making there.
bobmcnamara 8 hours ago
kelseyfrog 11 hours ago
wizzwizz4 9 hours ago
People who believe these types of things tend to get their information from the same places. Which podcasts do you listen to?
mrweasel 7 hours ago
chasil 7 hours ago
Powdered sugar is the standard treatment for removing varroa mites that have emerged from capped cells.
"The peptides killed only the mites, while the bees survived."
What benefits do these new treatments offer? They certainly won't be cheaper.
https://www.honeybeesuite.com/can-powdered-sugar-control-var...
Edit: "Treatments every week killed more mites than treatments every two weeks, which killed more mites than treatments every month... The only treatment schedule that effectively suppressed mites over long periods was once per week... sugar dusting has been found to significantly reduce adult mite populations at times when little brood is present."
m4x 6 hours ago
There currently isn't a effective treatment for varroa that doesn't also kill the hive. It is not a solved problem, and there is certainly room for more research in this space.
lavela 3 hours ago
I am pretty sure I read that Bees would be capable of taking care of mites themselves, but taking away their honey puts them in constant food stress, thus suppressing that behavior, and compresses the colony thus increasing mite density. Can't find a proper study right now though.
bspammer 6 hours ago
The article you linked lists a bunch of downsides to powdered sugar: it doesn’t kill the mites it just encourages the bees to brush them off, it has reduced effectiveness when it’s humid, it doesn’t work on mites that aren’t actively on a bees body, and it has to be applied regularly.
benbojangles 9 hours ago
One day bees will evolve to produce spider venom
mrweasel 8 hours ago
Asian bees are perfectly capable of removing and killing mites as is. So are some breed species of European honey bees. There have been found abandoned apiary in France where the bees have evolved to groom themselves and remove the mites.
The bees does need to evolve, but not to the point of producing venom. Mechanical mite removal works equally well.
speed_spread 7 hours ago
I was rather thinking of bees developing the ability to shoot tiny lasers to cook the mites off like popcorn. Or maybe a static discharge from their wings rubbing together, like a natural taser.
roboben 4 hours ago
mite popcorn with fresh honey sounds like a three star dish for $67
blooalien 12 hours ago
Some potentially seriously good news there if it all pans out the way it sounds like it might. Fingers crossed for the bees!
shevy-java 11 hours ago
This assumes the mites are what kills the bees. What is that asssumption is flawed?
EdwardDiego 10 hours ago
Then all the scientists who study apiary are wrong and someone in the HN comments knows better than all of them.
Congratulations, I look forward to your Nobel prize.
somenameforme 2 hours ago
thin_carapace 6 hours ago
blooalien 5 hours ago
This assumes no such thing at all (as I'm clearly no expert on bees), but it does assume that literal parasites cannot possibly be a good thing for the bees, and anything that genuinely helps the bees is a net plus for us all.
fodkodrasz 11 hours ago
Nah, it cannot happen that Big Agro's poisons are to fault...
niksmather 11 hours ago
EdwardDiego 10 hours ago
skeeter2020 3 hours ago
we're going to need a lot of very tiny syringes and band-aids!
mjanx123 6 hours ago
IIRC the Asian honey bee is more resilient to mites
CommonGuy 4 hours ago
Yes, they remove the mites if they detect them. Asian honey bee colonies usually do not collapse from varroa mites.
But since European honey bees produce much more honey, the are the prefered species and used worldwide
tamimio 9 hours ago
Kinda related, but in my house I don’t kill spiders, as long as they are in the corners they can live rent free while cleaning other bugs. Before, one time I went and killed all of them, in less than a week I started seeing sliverfish and similar bugs, I realized I messed up the natural order, so I just keep em now!
brikym 9 hours ago
I leave the wolf spiders as they don't make webs.
taneq 7 hours ago
In my old house we sprayed for spiders and ants, and a few weeks later there were cockroaches everywhere. I guess it was just a coincidence. >.>
aussieguy1234 11 hours ago
So what's it going to do to the honey? Will we have spider venom laced honey?
hyperionultra 11 hours ago
As article suggest - it is fully biodegradable. I suppose venom has some short half-life. And since peptide is isolated, not full chain toxin, it should be harmless to humans.
gadders 10 hours ago
I'd imagine eating it has a different effect than having it directly enter the bloodstream as well.
taneq 7 hours ago
karlkloss 10 hours ago
A lot of people might become allergic to honey, and never know why.
mjmas 11 hours ago
Probably, but not at any meaningful concentration.
Coneylake 9 hours ago
Another terrible MCU spin-off
onesandofgrain 8 hours ago
How did they screen for this venom?
throwaway2037 7 hours ago
Too lazy to read an article that takes about one minute? Sheesh.
> “We screened 50 venoms, mostly from spiders and scorpions, by applying them externally to the mites,” says Herzig.
> “We found more than 75% killed the mites within 24 hours. We selected 2 of the most potent spider venoms for further analysis.”Luckyemmet 7 hours ago
Genuinely thought this was a new marvel character lol
shevy-java 11 hours ago
Still the honeybees keep on dying ...
Perhaps it is time to stop blaming the mites for the decline of the honeybees.
mrweasel 9 hours ago
The Danish beekeeping association has a list of their top four reasons for declining bee populations (both honeybees and wild bees). None of them are mites. Multiple experiments and analysis of abandoned beehives show time and time again that the bees will develop coping mechanisms against varroa mites if we let them.
All four reasons are linked to a decline habitats suitable for bees.
* Lose of natural habitats.
* Fertilization close to natural habitats causes grass to grow and outcompete bee friendly plants.
* Herbicides are killing flowers.
* Pesticides hurt wild bees (honeybees to a less extend).
What is killing bees more rapidly than anything is modern farming. When you see farmers, especially those in the US, needing to truck around bees it should be abundantly clear that something has gone very wrong. Massive fields and orchards with a single crop is no place for a bee, they simply have no food for the majority of the year. What do we expect bees to do with 50 acres of corn or wheat? To a bee that might as well be a desert.